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The present invention relates to a kind of Vardenafil hydrochloric acid oral solid formulation that is stable, Fast Stripping and preparation method thereof.Said preparation for active drug with Vardenafil hydrochloric acid trihydrate, is equipped with the adjuvants such as filler, disintegrating agent, antioxidant, correctives, fluidizer, lubricant, adopts pharmaceutically acceptable
Alternate CAS#: Molecular Formula: C 23 H 32 N 6 O 5 S. Molecular Weight: 504.61 Vardenafil (VRD) and sildenafil (SLD) are phosphodiesterase-5 (PDE5) inhibitors available by prescription in the U.S. for the treatment of erectile dysfunction. The two compounds are structurally very similar, with differences only in the position of a nitrogen in the fused heterocyclic rings and the alkyl group (ethyl for VRD, methyl for SLD) attached to the piperazine ring ( Fig.␣1 ). Naloxone N-Oxide.
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EXAMPLE 3 . Stability and biological demonstration of the good tolerability and exceptional bioavailability of formulations of the invention
Vardenafil is used to treat erectile dysfunction in men. It is an oral therapy for the treatment of erectile dysfunction. It is sold under the trade names Levitra, Staxyn, and Vivanza.Reference standards of Vardenafil API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below. Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.
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Ledande sponsor: University Hospitals Cleveland Medical Center.
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